Bisphosphonate-related osteonecrosis of the jaw: the role of actinomyces.
نویسندگان
چکیده
The etiology of bisphosphonate-related osteonecrosis of the jaw is unknown but was initially postulated to be mediated by bisphosphonate accumulation within the jaws, resulting in avascular necrosis. Bisphosphonates may not be the primary cause. Actinomyces are an underrecognized agent in pathogenesis, and timely actinomycosis-specific treatment may improve outcome.
منابع مشابه
Bisphosphonate Related Osteonecrosis of the Jaw: A Study of 18 Cases Associated with Fungal Infection
Osteonecrosis of the jaw (ONJ) is a serious complication associated with oral and intravenous bisphosphonate therapy. Its pathogenesis is not well understood and its management is difficult. Microbiological investigations have detected a variety of oral pathogens such as Actinomyces, Enterococcus, Candida albicans, Aspergillus, Haemophilus influenzae, alpha-hemolytic streptococci, Lactobacillus...
متن کاملPathophysiology of osteonecrosis of the jaw in patients treated with bisphosphonate.
Apart from the well-known mechanism of bisphosphonates' cellular effect, embryonic development and the specific features of alveolar bone homeostasis have been discussed. The unique ethiopathogenic mechanism which relates osteonecrosis of the jaw and bisphosphonates treatment has not been explained. The emphasis lies on the toxicological effects of bisphosphonates on the physiology of the alveo...
متن کاملThe association of medication-related osteonecrosis of the jaw with Actinomyces spp. infection
Medication-related osteonecrosis of the jaw (MRONJ) represents a complication of bisphosphonate treatment that responds poorly to standard treatment. In a retrospective cohort study we investigated a possible role of Actinomyces spp. in the pathogenesis of MRONJ. Deep biopsies of necrotic bone were collected during surgical treatment of MRONJ and evaluated by histology and microbiology for the ...
متن کاملBiomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2013; 157:XX
Aim. This article covers the authors‘ experience with the treatment of bisphosphonate-related osteonecrosis of the jaw in 11 individuals. Methods. A retrospective study of patients diagnosed and treated for bisphosphonate-related osteonecrosis of the jaw at the Department of Dentistry, University Hospital Hradec Králové during the period January 2006 to October 2012. The treatment protocol cons...
متن کاملBiomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2015 Jun; 159(2)
Aim. This article covers the authors‘ experience with the treatment of bisphosphonate-related osteonecrosis of the jaw in 11 individuals. Methods. A retrospective study of patients diagnosed and treated for bisphosphonate-related osteonecrosis of the jaw at the Department of Dentistry, University Hospital Hradec Králové during the period January 2006 to October 2012. The treatment protocol cons...
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ورودعنوان ژورنال:
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
دوره 49 11 شماره
صفحات -
تاریخ انتشار 2009